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25I-NBOMe (also known as 2C-I-NBOMe, NBOMe-2C-I, Cimbi-5 and N-Bomb) is a psychedelic substance of the phenethylamine chemical class that produces an array of visually-dominant and stimulating psychedelic effects when administered.
It was first synthesized and documented in 2003 by Ralf Heim at the Free University of Berlin. It was further researched by a team at Purdue University led by David Nichols. It has been studied in its 11C radiolabelled form as a potential ligand for mapping the distribution of 5-HT2A receptors in the brain, using positron emission tomography (PET).
Extremely little is known about the pharmacological properties, metabolism, and toxicity of 25I-NBOMe in humans. It had no history of human use before being sold online as a designer drug. It has been associated with many deaths and hospitalizations. Anecdotal reports suggest that this substance may be difficult to use safely due to its highly sensitive dose-response and unpredictable effects.
Side Effects of Use
25I-NBOMe effects usually last 6–10 hours if taken sublingually, or buccally (between gum and cheek). When it is Insufflated (snorted), effects usually last 4–6 hours. It can be consumed in liquid, powder or paper form and can be snorted, injected, mixed with food, or smoked, but sublingual administration is most common
25I-NBOMe has similar effects to LSD, though users report more negative effects while under the influence and more risk of harm following use as compared to the classical psychedelics.
Most common side effects include; hypertension agitation, aggression, visual and auditory hallucinations, seizures and elevated white cell count.