Methylone is an analytical reference material that is categorized as a cathinone. Methylone blocks reuptake of dopamine, 5-HT, and norepinephrine in rat synaptosomes (IC50s = 2.9, 2.3, and 0.74 µM, respectively).1 It also induces release of the same neurotransmitters from synaptosomes (EC50s = 0.38, 0.22, and 0.093 µM, respectively). It has been detected in products marketed as bath salts, plant food, and tablets. This product is intended for research and forensic applications.
Methylone is the substituted cathinone analog of MDMA and the 3,4-methylenedioxy analog of methcathinone. The only structural difference of methylone with respect to MDMA is the substitution of 2 hydrogen atoms by 1 oxygen atom in the β position of the phenethylamine core, forming a ketone group.
Methylone is used to treat pain and swelling that occurs with arthritis and other joint disorders. This medication may also be used to treat various conditions such as blood disorders, severe allergic reactions, certain cancers, eye conditions, skin/intestinal/kidney/lung diseases, and immune system disorders. It decreases your immune system’s response to these conditions and reduces symptoms such as swelling, pain, and allergic-type reactions.
Dosage and Administration
- Threshold: 60-120 mg
- Low dose: 100-150 mg
- Average dose: 100-250 mg
- Strong dose: 160-270 mg
- Heavy dose: 250 mg
Caution! Every person is different. So be careful when you first start using a new substance. It may be that you tolerate less than you would expect. Good experience with MDMA doesn’t mean you will respond well to Methylone. Conversely the same applies. Always start with a low dose and see what it does to you.
Effects of Methylone
Methylone takes effect within 20-30 minutes after intake.
- Euphoric feelings
- Improved concentration
- Strong tendency to talk
- Increased energy
- Possible tingling sensations in the body, especially on top of the skull
- Possible increased libido
- Greater capacity for empathy
- Reduced anxiety and insecurity
- Hallucinations are possible with a high dose, which usually means the dose was too high. In sensitive persons these effects can already occur at a lower dose.
- Loss of appetite
- Slightly rolling eyes
- Increased blood pressure and heart rate
- Increased body temperature
- Difficulty urinating
- Dry mouth
- Large pupils
- Stiff jaws, at high doses the mandible can start flapping
- In some cases: blurred vision
- A high dose can lead to nausea and vomiting